The 35-point margin of defeat was the largest of the season for Washington State (9-12, 2-9).
The Wildcats' (17-6, 9-2) inside play was the key as Arizona scored 50 points in the paint, including 10 dunks.
"They're better than we are," WSU head coach Paul Graham said. "They're bigger and stronger. They pounded us inside with Woods and (Michael) Wright. That is a basketball team picked to win the national title and they are better than us at every position."
Wright added 10 points and a game-high seven rebounds for the Wildcats. Jason Gardner added a dozen points and Richard Jefferson chipped in with 10 points. Arizona pulled its starters with about 12 minutes left in the game.
WSU's Mike Bush (Riverside, Calif.) was held to three points on 1-of-9 shooting, marking only the second time this season the junior has failed to score in double figures. The other occasion was a nine-point effort against the Wildcats, January 11 in Spokane.
The Wildcats set the tone early with three dunks in the first 2:24 to take an 8-3 lead. The Wildcats shot 58 percent in the first half and led 49-27 at the half.
Arizona's shooting in the second half rose to 65 percent and the Wildcats finished at 60 percent for the game.
Sophomore Milton Riley (Gardena, Calif.) led Washington State with 10 points and added four rebounds and a pair of blocks.
The Cougars host Oregon Thursday, February 15 at 7 p.m. at Friel Court.